Dr. Saranya Wyles

Dr. Saranya Wyles, M.D., Ph.D., is the Director of the Regenerative Dermatology and Skin Longevity Laboratory at Mayo Clinic, where she leads NIH-funded research focused on regenerative biotherapies for inflammatory and age-related skin conditions. Her groundbreaking work has defined the cellular mechanisms of skin aging, including the development of skin-specific senescence gene sets known as SenSkin, with findings published in Nature Aging and Aging Cell. She also holds two U.S. patents for methods to reduce scar formation and has patent-pending technologies in 3D skin bioprinting. A key focus of her lab is designing innovative 3D bioprinted skin aging and disease models to support preclinical testing aligned with FDA initiatives.

In addition to her research, Dr. Wyles is Associate Education Director at Mayo Clinic’s Center for Regenerative Biotherapeutics, where she develops training programs in regenerative science for future healthcare professionals. A board-certified dermatologist, she completed her M.D.-Ph.D. at Mayo Clinic and furthered her expertise with fellowships at the Harvard Stem Cell Institute, Wake Forest School of Medicine, and King’s College London. Her work has earned her national and international recognition, including scientific achievement awards and the NIH National Institute on Aging’s Butler-Williams Scholarship. She was also featured on NBC’s Today Show in a segment exploring the role of “zombie cells” in aging.